The Significance of chromosomally integrated HHV-6 in cardiological diseases
DOI:
https://doi.org/10.69139/k91tkf37Keywords:
Chromosomal integration, Heart failure, HHV-6, Inflammatory dilated cardiomyopathy, MyocarditisAbstract
HHV-6 is a double-stranded DNA β-herpesvirus known for inducing sudden erythema. It may elicit a cytopathic effect on the host's cells, resulting in acute infection. Furthermore, HHV-6 might be integrated into the genome of the host and might activate in favorable conditions like immunosuppression. Thus, HHV-6 may persist for the whole life of the infected cell. The described virus might be aetiological factor of various diseases e.g. multiple sclerosis, Alzheimer's disease, ectodermal dysplasia, and myocarditis. Moreover, the presence of chromosomally integrated HHV-6 might be a negative prognosis factor for a heart transplantation. Thus, the diagnostics of the virus is significant.
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Copyright (c) 2025 Maciej Baron, Piotr Lewandowski MD, Marcin Rojek, Małgorzata Wachowicz, Łukasz Zniszczoł (Author)
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